hwhghttp://goehlmann.infoHinrich GoehlmannFri, 29 Jan 2016 08:52:08 GMTFri, 29 Jan 2016 08:52:08 GMTblogFuguHub1440<![CDATA[Minecraft on old Lenovo M58p]]>http://goehlmann.info/blog/2016/01/Minecraft-on-old-Lenovo-M58p Minecraft

I have purchased an old M58p and tried my luck to upgrade it somewhat. Swapping the hard drive for a SSD was fairly straight forward. However, getting to install Windows 10 and then finding the right drivers was a bit more challenging...

In the unlikely event that you are trying the same - or that you are also struggling to get Minecraft running on such a machine, you will know that there are issues with OpenGL and finding a working graphics driver for the Intel Q45/Q43 express chipset. The following driver works for me - even though the frame rate is not spectacular, it does work decently if you reduce your settings:

b2vdo11us14.exe - Intel Onboard VGA driver for Windows 7 (64-bit - old version from March 2010)
w4aud06us17.exe - ADI Audio codecs AD1988A and AD1882 driver
c3amt02us17.exe - Intel Active Management Technology driver

ThinkCentre M58p
Machine type: 6136

Good luck!

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blogFri, 29 Jan 2016 08:52:08 GMT
<![CDATA[PuberPester or how to sensibly provide internet access for kids]]>http://goehlmann.info/blog/2015/05/PuberPester-or-how-to-sensibly-provide-internet-access-for-kids DrayTek Vigor Router

More and more schools rely on parents to provide their children with internet access. Whether we are talking about websites to check the agenda for the next school day, get to know the scores from the latest exams or to find out whether a lesson will be dropped tomorrow due to the absence of one of the teachers, more and more is done via internet.

Sure, this is only logical as the society is moving towards an internet-enabled system for many aspects of life. Still, parents are left to their own devices on how to deal with this necessity at home. What, if you don't favor the two extremes of either no internet for the kids or completely free access? There are middle grounds like a computer at a table where mom or dad can have an eye on things every now and then. But isn't that a form of policing?

What if you want to deal with the whole situation in a way that tries to balance the necessity for access with certain restrictions while leaving as much as possible liberty for the kids? And don't forget to throw in some extra complexity such as smartphones and tablets - not just Windows desktops or laptops!

A daunting task...

I have taken it on with a compromise: provide a system that gives each kid a time quota. They need to log in and then the clock starts ticking across all devices. I have combined this further with some web site restrictions via OpenDNS. The system works for all devices as the accounts are linked to each kids own device and via account log-in for the shared devices. Furthermore, there are restrictions regarding time of day to ensure that internet is off during the night.

But what if your oldest one comes to tell you that his time is up and he still needs to check something for school?

Here my solution is a separate "school" account. It has unlimited access and only works on white-listed sites (those sites absolutely needed for school). And what when they figure out that it is difficult to deal with https sites? To prevent endless YouTube watching via the school account, there is a data quota of 50 MB per day on that account ("op is op" as they say in Dutch).

Is this the best solution? Probably not. But it is my current attempt to strike a balance between providing the needed access to the internet while restricting it in a way that limits policing...

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blogMon, 25 May 2015 21:15:50 GMT
<![CDATA[Replacing my Nexus 5 battery]]>http://goehlmann.info/blog/2015/02/Replacing-my-Nexus-5-battery LG BL-T9 2300mAh replacement battery

This was the first time I have attempted to replace a smartphone battery. After having used an iPhone 3GS for several years (with two battery replacements done by someone who knew what he was doing...) I had switched to a Nexus 5 end of 2013.

It was peculiar that I had all kinds of strange crashes after having moved to Lollipop. I tried various battery saving apps, but at some point wondered whether replacing the battery would not be more sensible. So I got a LG BL-T9 2300mAh replacement battery and went ahead with a knife and a screwdriver. And I must say, it was not that difficult.

I found the descriptions at IFixIt quite useful. Even though they mention "The battery is held in place with some adhesive.", it took me quite a while to finally apply sufficient force (= not too much - it requires some patience) to get the battery out. To my surprise the battery had "swollen" a bit and felt a bit spongy - certainly when comparing to the new replacement battery. I only recall that the Nexus had gotten somewhat warmer the weeks before I had ordered a new battery, so I wonder whether my battery had become funny...

One last remark: I found descriptions where they start by placing the new battery first and then attach the daughter board connector. If you have no experience, the connector feels unknown and you wonder whether you are placing it properly. I removed the battery again and first attached the connector before placing the battery. That was much easier.

All in all, really something that can be done if you have some patience and don't apply too much force.

The IFixIt article can be found here:
https://www.ifixit.com/Guide/Nexus+5+Battery+Replacement/26009
And here is an image of another Nexus 5 user who had a similarly "swollen" battery:
http://i.imgur.com/CZW0l7u.jpg

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blogWed, 18 Feb 2015 11:59:18 GMT
<![CDATA[Bedaquiline for Patients with NTM Lung Disease?]]>http://goehlmann.info/blog/2015/02/Bedaquiline-for-Patients-with-NTM-Lung-Disease Structure of TMC207/R207910

The journal Chest has recently published an article describing an off-label use of Bedaquiline (TMC207/R207910). Philley et al. have explored the effects of the drug in patients with nontuberculous mycobacterial (NTM) lung disease. They treated in total 10 patients with the same bedaquiline dosage used in TB trials.

While the authors clearly point at the small sample size of the study, they did not observe abnormal EKG findings - something which is of concern as the drug has a black-box warning for arrhythmias (=> long QT syndrome).

I hope we will be able to quickly gather more information over potential long QT risks so that we get a better view on the risk/benefit balance.

You can find the article here:
http://journal.publications.chestnet.org/article.aspx?articleID=2119207

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blogFri, 13 Feb 2015 18:08:43 GMT
<![CDATA[Toxic tuberculosis drug]]>http://goehlmann.info/blog/2015/01/Toxic-tuberculosis-drug Structure of TMC207/R207910

I admit I am biased. I have contributed to our understanding of the molecular mechanisms of bedaqueline and wish the drug to become a successful aid in curing patients with MDR-TB. Therefore I was concerned and curious to learn more when I saw this heading twice on 31st of December:

"New treatment strategy allows lower doses of toxic tuberculosis drug without compromising potency"

Of course, learning that a person is working in / for the pharmaceutical industry triggers a broad spectrum of associations with different people. Similarly, for me reading characterizations such as "toxic tuberculosis drug" or "higher toxic doses of bedaquiline" bring up associations of bad news as you would not want people to be treated with "toxic drugs".

After reading the articles I came to realize that the choice of words for the heading might have been too strong as also one of the authors (Dr. Gupta) states in an interview: "In a phase 2 trial involving patients with advanced MDR-TB, a significantly higher number of participants receiving bedaquiline died than those receiving placebo although the causes of mortality were not directly attributable to the drug."

Over the next two days I stumbled across two more sites referring to the same research. Here the headings read a little differently: "Hypertension Medication May Enhance Tuberculosis Treatment" and "Study indicates new strategy to treat tuberculosis".

Choosing the right words for a heading sure is difficult - especially when they concern words that elicit an emotional response in some readers. To me "toxic" is one of them.

Here are the articles I am referring to:
http://www.eurekalert.org/pub_releases/2014-12/jhm-nts123014.php
http://medicalxpress.com/news/2014-12-treatment-strategy-doses-toxic-tuberculosis.html
http://medicalresearch.com/infections/hypertension-medication-may-enhance-tuberculosis-treatment/10317/
http://vaccinenewsdaily.com/news/332489-study-indicates-new-strategy-to-treat-tuberculosis/

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blogFri, 02 Jan 2015 22:38:46 GMT