Bedaquiline for Patients with NTM Lung Disease?

Friday, February 13th, 2015 by hinrich

Structure of TMC207/R207910

The journal Chest has recently published an article describing an off-label use of Bedaquiline (TMC207/R207910). Philley et al. have explored the effects of the drug in patients with nontuberculous mycobacterial (NTM) lung disease. They treated in total 10 patients with the same bedaquiline dosage used in TB trials.

While the authors clearly point at the small sample size of the study, they did not observe abnormal EKG findings - something which is of concern as the drug has a black-box warning for arrhythmias (=> long QT syndrome).

I hope we will be able to quickly gather more information over potential long QT risks so that we get a better view on the risk/benefit balance.

You can find the article here:

Posted in Tuberculosis