Effects of TMC207/R207910 against leprosy bacteria

Monday, November 09th, 2009 by hinrich

Structure of TMC207/R207910

Ji et al. suggested in their publication in 2006 that TMC207/R207910 may play a role in the treatment of leprosy.

Now Gelber et al. have shown that indeed TMC207/R207910 has a bactericidal effect for Mycobacterium leprae-infected mice. In their dose frequency study they examined three different treatments (five times weekly, once weekly, and once monthly) and demonstrated that all dosage schedules were bactericidal for M. leprae. They furthermore gathered evidence that TMC207/R207910 prevented multiplication of the bacteria for a prolonged period of time after the treatment had ended.

Having shown the bactericidal effects of TMC207/R207910 for M. leprae during logarithmic multiplication, the authors conclude that these findings should merit a clinical trial with leprosy patients once long-term safety data for TMC207/R207910 are available. Especially since Mycobacterium leprae has a longer generation time in comparison with Mycobacterium tuberculosis, a successful addition of TMC207/R207910 to a potentially monthly regimen with shorter duration than the current standard therapy might become possible.

More detailed information can be found in the article.

Posted in Tuberculosis


Automatic access point selection based on signal strength

Sunday, November 08th, 2009 by hinrich

It is convenient that Windows XP - yes I still use this system and I am only playing with the Windows 7 release candidate at the moment -  allows us to store the settings plus passwords for the wireless access points we regularly use. I also appreciate the ability to store a ranking - like which access point the system will attempt to connect to first.

However, what is the point of this ranking when the software does not take the signal strength of the access point into consideration? What good does it do when my computer always connects me to the access point in the top of the list while the second one might be much closer by and could provide me with a much better connection?

Please, make use of all the data and come up with a smart ranking of wireless access points instead of just a static one!

Posted in Computer


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