USB status monitors

Friday, April 17th, 2009 by hinrich

USB-powered status monitors

Over the past months we have seen a wave of all kinds / sizes / prizes of digital photo frames. While I like the idea in principle, I always disliked that most of them needed a separate power supply. Furthermore, they are fully functional monitors but only show pictures. I would love to see more USB-connected monitors that purely serve the purpose of status monitors. You cannot extend your desktop with them, but in fact you use them for things that are on the real desktop, but often get hidden, unless you have a very big screen. Such monitors would be small - maybe 7 inches. Their only purpose would be to display information - maybe in a slideshow kind of way. This could be my ToDo list, replacements for all the yellow sticky notes, current PC status infos, current weather forecasts, snapshots of my most important web sites so that I can see altered content, etc.

Of course, this would need to be done in such a way that it is possible to avoid distractions. Possibly by providing a power button and some functionality to flip through the info pages if needed.

Posted in Computer

Having fun with LaTeX / LyX

Wednesday, April 15th, 2009 by hinrich


We have finished the text and all corrections are inserted. Even the color conversions from RGB to CMYK worked out - thanks to ImageMagick and this Windows command:
for %f in (*.png) do convert %f -profile sRGB.icm -profile USWebCoatedSWOP.icc %~nf.pdf
We have now given ourselves until next Tuesday to finalize the layout. Here are some "lessons learned" that I found difficult to locate on the internet:

Posted in Misc

ATP synthase selectivity of TMC207/R207910

Thursday, April 02th, 2009 by hinrich

Article by Haagsma et al.

I have written previously about the >20.000 fold lower sensitivity of TMC207/R207910 on the human mitochondrial ATP synthase in comparison to the ATP synthase of Mycobacterium smegmatis.

The article has now been published in the March 2009 edition of Antimicrobial Agents and Chemotherapy. It nicely shows the clear difference in activity of TMC207/R207910 on the ATP synthase from human mitochondrial ATP synthase (derived from the human ovarian cancer cell line OVCAR3) in contrast to the ATP synthase of the Mycobacterium strain Mycobacterium smegmatis mc2155.

I like the last sentence of the paper that highlights how the disqualification of a bacterial protein as a potential drug target should not be done: "More generally, our results illustrate that in drug discovery, a protein should not be disregarded a priori as a potential drug target because of the existence of a human homologue".

You can read the abstract of the paper here.

Posted in Tuberculosis